IL-6 Antibodies

Interleukin-6 (IL-6) has a molecular weight of approximately 21-28 kDa. This cytokine is produced by various cell types, including T cells, B cells, monocytes, fibroblasts, and endothelial cells, and secreted in response to various stimuli, such as infection, injury, or inflammation.

Interestingly, IL-6 is a multifunctional cytokine with pro-inflammatory and anti-inflammatory properties, playing crucial roles in immune responses, inflammation, and the regulation of hematopoiesis. The dysregulation of Interleukin-6 is associated with various inflammatory and autoimmune diseases. For example, elevated levels are found in conditions such as rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease, and during severe infections.

Antibodies against IL-6 are used in research to detect and quantify Interleukin-6 levels in biological samples. Immunohistochemistry, ELISA, and other immunoassays employing anti-IL-6 antibodies help researchers study its role in different diseases and conditions. In a clinical context, IL-6 levels may be measured as part of diagnostic tests to assess the extent of inflammation or to monitor disease activity. Therapeutically, antibodies targeting Interleukin-6 or its receptor (e.g., tocilizumab) are used to treat autoimmune diseases like rheumatoid arthritis and certain inflammatory conditions. Furthermore, these inhibitors are being explored for their potential in managing cytokine storms associated with severe infections, including those seen in some cases of COVID-19.

Synonyms

Interleukin-6, B-cell stimulatory factor 2, CTL differentiation factor, Hybridoma growth factor, Interferon beta-2, B-cell stimulatory factor 2 (BSF-2); CTL differentiation factor (CDF); Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor (HSF); HPGF; Hybridoma growth factor Interferon beta-2; Hybridoma plasmacytoma growth factor; IFN-beta-2 (IFNB2)

Research Areas

Cardiovascular, Immunology, AKT Signaling, Colon Cancer, Cytokine Signaling, Dendritic Cell Marker, Hematopoietic Stem Cells, Infectious Disease, Mesenchymal Stem Cell Differentiation, Neuroinflammation, Signal Transduction, Stem Cell Differentiation, Transcription Factors