IL-6 Antibodies

Interleukin-6 (IL-6) has a molecular weight of approximately 21-28 kDa. This cytokine is produced by various cell types, including T cells, B cells, monocytes, fibroblasts, and endothelial cells, and secreted in response to various stimuli, such as infection, injury, or inflammation.

Interestingly, IL-6 is a multifunctional cytokine with pro-inflammatory and anti-inflammatory properties, playing crucial roles in immune responses, inflammation, and the regulation of hematopoiesis. The dysregulation of Interleukin-6 is associated with various inflammatory and autoimmune diseases. For example, elevated levels are found in conditions such as rheumatoid arthritis, systemic lupus erythematosus (SLE), inflammatory bowel disease, and during severe infections.

Antibodies against IL-6 are used in research to detect and quantify Interleukin-6 levels in biological samples. Immunohistochemistry, ELISA, and other immunoassays employing anti-IL-6 antibodies help researchers study its role in different diseases and conditions. In a clinical context, IL-6 levels may be measured as part of diagnostic tests to assess the extent of inflammation or to monitor disease activity. Therapeutically, antibodies targeting Interleukin-6 or its receptor (e.g., tocilizumab) are used to treat autoimmune diseases like rheumatoid arthritis and certain inflammatory conditions. Furthermore, these inhibitors are being explored for their potential in managing cytokine storms associated with severe infections, including those seen in some cases of COVID-19.

Synonyms

Interleukin-6, BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6

Research Areas

Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors