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HGF / SF Antibody [EGH2 4C12.1]

In Stock
Catalog Number Formulation Size Price
3082-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3082-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3082-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Gene Name
HGF
Positive Control
HGF lysate.
Immunogen
Recombinant full-length human HGF/SF protein.
Alternate Names
Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, F-TCF; Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor (hepapoietin A; scatter factor); Hepatocyte growth factor beta chain; Hepatopoietin-A; HGF; HGFB; HPTA; Lung fibroblast derived mitogen; Scatter Factor

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
EGH2 4C12.1
Chromosome Location
7q21.11
Mol. Weight of Antigen
91/64/34kDa precursor//

Functions

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Key References

  • Miyazawa, K., et al. 1994. J. Biol. Chem. 269: 8966-8970.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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