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HER-2 / c-erbB-2 / neu / CD340 Antibody [ERB2/776]

Additional information

Catalog Number: 2064-MSM6
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2064-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2064-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2064-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
HER-2 / c-erbB-2 / neu / CD340 Antibody

Flow Cytometric Analysis of human trypsinized MCF-7 cells using HER-2 Mouse Monoclonal Antibody (HRB2/776) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).

HER-2 / c-erbB-2 / neu / CD340 Antibody - Image 2

Immunofluorescent staining of MeOH-fixed MCF-7 cells with HER-2 Mouse Monoclonal Antibody (HRB2/776) followed by goat anti-Mouse IgG-CF488 (Green). Nuclei are stained with Reddot (Red).

HER-2 / c-erbB-2 / neu / CD340 Antibody - Image 3

Immunofluorescent staining of PFA-fixed MCF-7 cells with HER-2 Mouse Monoclonal Antibody (HRB2/776) followed by goat anti-mouse IgG-CF488 (Green). Nuclei are stained with Reddot (Red).

HER-2 Antibody in SDS-PAGE

HER-2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified HER-2 Mouse Monoclonal Antibody (HRB2/776). Confirmation of Integrity and Purity of Antibody.

  • ELISA
  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Clone
ERB2/776
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane, Cytoplasm, Early endosome, Nucleus, Perinuclear region
Gene Name
ERBB2
Positive Control
MCF-7, SKBR-3 cells. Breast Cancers.
Immunogen
Recombinant intracellular domain of human HER-2 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
  • In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Key References
  • Wright C, et al. British Journal of Cancer. 65: 118-121 (1992).
  • Utrilla JC, et al. Histopathology. 34: 60-65 (1999).
  • Corbett IP, et al. Journal of Pathology. 161: 15-25 (1990).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2064
SwissProt
P04626
Chromosome Location
17q12
Mol. Weight of Antigen
185kDa
Alternate Names
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185, CD340, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog

Summary

This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

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