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Formalin-fixed, paraffin-embedded human skin stained with HB-EGF Mouse Monoclonal Antibody (HBEGF/9503). Inset: PBS instead of primary antibody; secondary only negative control.
Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface and extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis.
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