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HBEGF / DTR Antibody [HBEGF/9503]

In Stock
Catalog Number Formulation Size Price
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)


Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface and extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis.

Product Properties & Targets

Antibody Type
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cell membrane, Membrane, Secreted
Gene Name
Positive Control
RAW 264.7
Recombinant fragment (around aa1-208) of human HBEGF protein (exact sequence is proprietary)
Alternate Names
proheparin-binding EGF-like growth factor, diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody; diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody; Diphtheria toxin receptor antibody; DT R antibody DT-R antibody; DTR antibody; DTS antibody; DTSF antibody; HB-EGF antibody; HBEGF antibody; HBEGF_HUMAN antibody; HEGFL antibody; Heparin binding EGF like growth factor antibody; Heparin binding epidermal growth factor antibody; Heparin binding epidermal growth factor like growth factor antibody; Heparin-binding EGF-like growth factor antibody; Proheparin binding EGF like growth factor antibody, diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); heparin-binding epidermal growth factor

Database Links

Entrez Gene ID

Additional Information

Chromosome Location
Mol. Weight of Antigen


  • May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Key References

  • Yang CC, Chang KW. Eicosanoids and HB-EGF/EGFR in cancer. Cancer Metastasis Rev. 2018;37(2-3):385-395. doi:10.1007/s10555-018-9746-9
  • Hsieh CH, Chou YT, Kuo MH, Tsai HP, Chang JL, Wu CW. A targetable HB-EGF-CITED4 axis controls oncogenesis in lung cancer. Oncogene. 2017;36(21):2946-2956. doi:10.1038/onc.2016.465
  • Yotsumoto F, Fukagawa S, Miyata K, et al. HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of EGFRT790M. Anticancer Res. 2017;37(7):3825-3831. doi:10.21873/anticanres.11761
  • Nishikawa K, Asai T, Shigematsu H, et al. Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer. J Control Release. 2012;160(2):274-280. doi:10.1016/j.jconrel.2011.10.010

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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