HBEGF / DTR Antibody [HBEGF/9503]

• May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

• Yang CC, Chang KW. Eicosanoids and HB-EGF/EGFR in cancer. Cancer Metastasis Rev. 2018;37(2-3):385-395. doi:10.1007/s10555-018-9746-9
• Hsieh CH, Chou YT, Kuo MH, Tsai HP, Chang JL, Wu CW. A targetable HB-EGF-CITED4 axis controls oncogenesis in lung cancer. Oncogene. 2017;36(21):2946-2956. doi:10.1038/onc.2016.465
• Yotsumoto F, Fukagawa S, Miyata K, et al. HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of EGFRT790M. Anticancer Res. 2017;37(7):3825-3831. doi:10.21873/anticanres.11761
• Nishikawa K, Asai T, Shigematsu H, et al. Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer. J Control Release. 2012;160(2):274-280. doi:10.1016/j.jconrel.2011.10.010

• https://pubmed.ncbi.nlm.nih.gov/29936588/
• https://pubmed.ncbi.nlm.nih.gov/35342363/
• https://pubmed.ncbi.nlm.nih.gov/35102343/
• https://pubmed.ncbi.nlm.nih.gov/37155852/
• https://pubmed.ncbi.nlm.nih.gov/31885807/
• https://pubmed.ncbi.nlm.nih.gov/36284301/
• https://pubmed.ncbi.nlm.nih.gov/31882563/
• https://pubmed.ncbi.nlm.nih.gov/37567873/
• https://pubmed.ncbi.nlm.nih.gov/34742261/
• https://pubmed.ncbi.nlm.nih.gov/22020380/
• https://pubmed.ncbi.nlm.nih.gov/21976708/

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

1839

Q99075

5q31.3

23kDa

proheparin-binding EGF-like growth factor, diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody; diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody; Diphtheria toxin receptor antibody; DT R antibody DT-R antibody; DTR antibody; DTS antibody; DTSF antibody; HB-EGF antibody; HBEGF antibody; HBEGF_HUMAN antibody; HEGFL antibody; Heparin binding EGF like growth factor antibody; Heparin binding epidermal growth factor antibody; Heparin binding epidermal growth factor like growth factor antibody; Heparin-binding EGF-like growth factor antibody; Proheparin binding EGF like growth factor antibody, diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); heparin-binding epidermal growth factor