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GCHFR Antibody [GCHFR/7732]

Additional information

Catalog Number: 2644-MSM2
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2644-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2644-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2644-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
GCHFR Antibody

SDS-PAGE Analysis of Purified GCHFR Mouse Monoclonal Antibody (GCHFR/7732). Confirmation of Purity and Integrity of Antibody.

GCHFR Antibody - Image 2

Formalin-fixed, paraffin-embedded human liver stained with GCHFR Mouse Monoclonal Antibody (GCHFR/7732). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

GCHFR Antibody - Image 3

Western blot analysis of SK-BR3 cell lysate using GCHFR Mouse Monoclonal Antibody (GCHFR/7732).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
GCHFR/7732
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Lysosome.
Gene Name
GCHFR
Positive Control
Human liver or intestine.
Immunogen
Recombinant fragment human GCHFR protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Key References
  • Li L, Rezvan A, Salerno JC, et al. Circ Res. 2010;106(2):328-336. doi:10.1161/CIRCRESAHA.109.210658
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2644
SwissProt
P30047Human
Chromosome Location
15q15.1
Mol. Weight of Antigen
63kDa
Alternate Names
GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulatory protein, p35, GTP Cyclohydrolase I Feedback Regulatory Protein; GTP Cyclohydrolase I Feedback Regulator; GFRP; p35

Summary

GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. Cross-linking experiments have shown that GFRP is usually expressed as a homodimer or pentamer.

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