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Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody [PP13/8897]

In Stock
Catalog Number Formulation Size Price
29124-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
29124-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
29124-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

It recognizes a 32kDa protein, which is identified as homodimer of galectin-13 (also known as PP13). Galectins are a family of soluble β-galactoside-binding lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. One such member, galectin-13, is a 139 amino acid protein that contains one galectin domain. Possessing lysophospholipase activity, galectin-13 exists as a disulfide-linked homodimer. Galectin-13 is suggested to have a developmental role in the placenta and may display immunobiological activity in feto-maternal blood-spaces. Screening for galectin-13 in maternal serum during the first trimester of pregnancy may serve as a diagnostic marker to predict preterm pre-eclampsia.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cytoplasm. Cell surface.
Gene Name
Positive Control
K-562 cells. Placenta or Spleen.
Immunogen
Recombinant human Galectin-13 protein fragment (aa1-139) (exact sequence is proprietary)
Alternate Names
Galactoside-binding soluble lectin 13, Galectin-13, Placental tissue protein 13, Gal-13; GAL13; Galactoside-binding soluble lectin 13; Galectin-13; Galectin13; Lectin galactoside binding soluble 13; LGALS13; PLAC8; Placental protein 13 (PP13); Placental tissue protein 13

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PP13/8897
Chromosome Location
19q13.1
Mol. Weight of Antigen
16kDa (monomer); 32kDa (homodimer)

Functions

  • Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868).

Key References

  • Akolekar, R., et al. 2009. Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia. Prenat. Diagn. 29: 1103-1108.
  • Koster, M.P., et al. 2009. Placental protein 13 as a first trimester screening marker for aneuploidy. Prenat. Diagn. 29: 1237-1241

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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