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Erythropoietin (EPO) (Marker of Placentation Disorders) Antibody [EPO/1368]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
2056-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2056-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2056-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Recognizes a protein of about 37kDa, which is identified as Erythropoietin (EPO). Erythropoietin is a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. It is the primary factor responsible for regulating erythropoiesis during steady-state conditions and in response to blood loss and hemorrhage in the adult organism. Erythropoietin is synthesized by the kidney and stimulates the proliferation and maturation of bone marrow erythroid precursor cells. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
EPO
Positive Control
HepG2 cells. Heart or Kidney.
Immunogen
Recombinant fragment (around aa 28-162) of human EPO protein (exact sequence is proprietary)
Alternate Names
Erythropoietin, EP; EPO alpha; EPO; Epoetin; Erythropoietin; MVCD2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
EPO/1368
Chromosome Location
7q22
Mol. Weight of Antigen
37kDa

Functions

  • Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.

Key References

  • Jelkmann, W. 1992. Erythropoietin: structure, control of production, and function. Physiol. Rev. 72: 449-489.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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