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Colipase / CLPS Antibody [CLPS/9900]

In Stock
Catalog Number Formulation Size Price
1208-MSM10-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1208-MSM10-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1208-MSM10-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

The lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Members of the AB hydrolase subfamily include Hepatic Lipase (HL), Endothelial Lipase (EL), Lipoprotein Lipase (LPL), Pancreatic Lipase (PL), Gastric Lipase (GL) and LCAT. These family members play a crucial role in the metabolism of lipids. Pancreatic lipase, also designated pancreatic triacylglycerol acyl hydrolase, is important for dietary fat absorption as it hydrolyses triglycerides into diglycerides, monoglycerides and free fatty acids. Colipase, also known as CLPS or pancreatic colipase preproprotein, is a 112 amino acid secreted protein that functions as a cofactor of pancreatic lipase. Necessary for dietary lipid hydrolysis and localizing to pancreatic acinar cells, colipase allows pancreatic lipase to anchor itself to the lipid-water interface of lipid micelles, thereby preventing intestinal bile salts from washing it off.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human pancreas, breast cancer or esophagus cancer.
Immunogen
Recombinant fragment (around aa1-112) of human CLPS protein (exact sequence is proprietary)
Alternate Names
Colipase, COL_HUMAN; Colipase; Colipase pancreatic; Pancreatic colipase preproprotein

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CLPS/9900
Chromosome Location
6p21.31
Mol. Weight of Antigen
12kDa

Functions

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
  • Enterostatin has a biological activity as a satiety signal.

Key References

  • Sternby, B., et al. 1984. The primary sequence of human pancreatic colipase. Biochim. Biophys. Acta 784: 75-80.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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