Formalin-fixed, paraffin-embedded human Tonsil stained with Cdk1 Mouse Monoclonal Antibody (CDK1/873).

SDS-PAGE Analysis Purified Cdk1 Mouse Monoclonal Antibody (CDK1/873). Confirmation of Integrity and Purity of Antibody.

Western Blot Analysis of human HeLa cell lysate using Cdk1 Mouse Monoclonal Antibody (CDK1/873).

Cdk1 / p34cdc2 [CDK1/873]

Name: Cdk1 / p34cdc2
SKU: 983-MSM2
Availability: InStock

Monoclonals Mouse Monoclonals Primary Antibodies

Summary

Recognizes a 34kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. cdk1 / p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated cdk1 / p34cdc2 performs specific functions during mitosis, including nuclear envelope breakdown and chromosome condensation.

Printable

Product Properties & Targets

Host

Mouse

Species Reactivity

Cow, Human, Mink, Monkey

Isotype

IgG2a

Cellular Localization

Centrosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Mitochondrion, Nucleus, Spindle

Gene Name

CDK1

Mol. Weight of Antigen

34kDa

Immunogen

Recombinant human full-length CDK1 protein.

Database Links

Entrez Gene ID

983

Unigene

334562

SwissProt

P06493

Additional Information

Clone

CDK1/873

Human Gene Symbol

CDC2

Chromosome Location

10q21.2

Known Applications & Suggested Dilutions

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

Lukas J et. al. European Journal of Biochemistry, 1992, 207(1):169-76.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.