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Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody [rCD38/6447]

In Stock
Catalog Number Formulation Size Price
952-MSM9-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
952-MSM9-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
952-MSM9-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody

IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Strong cytoplasmic and membranous staining using rCD38/6447 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody - Image 2

IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using rCD38/6447 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody - Image 3

IHC analysis of formalin-fixed, paraffin-embedded human prostate adenocarcinoma. Strong cytoplasmic and membranous staining using rCD38/6447 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody - Image 4

SDS-PAGE Analysis of Purified CD38 Recombinant Mouse Monoclonal Antibody (rCD38/6447). Confirmation of Purity and Integrity of Antibody.

Recombinant CD38 (ADP Ribosyl Cyclase I) Antibody - Image 5

Western blot analysis of Raji cell lysate using CD38 Recombinant Mouse Monoclonal Antibody (rCD38/6447).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

CD38 is a type II transmembrane glycoprotein that is present on early B- and T-cell lineages and activated B- and T-cells but is absent from most mature resting peripheral lymphocytes. CD38 is found on thymocytes, pre-B cells, germinal center B-cells, mitogen-activated T-cells, monocytes and Ig-secreting plasma cells. CD38 is expressed on CD34+ cells. The CD34+CD38- population of hematopoietic stems cells define the most pluripotent cells (e.g.blast colony forming cells).

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
B Cell Markers, Hematopoietic Stem Cells
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Membrane
Gene Name
CD38
Positive Control
Human tonsil or spleen. Raji cells.
Immunogen
Synthetic peptide corresponding to residues within aa 200-300 of human CD38 (exact sequence is proprietary)
Alternate Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, Acute Lymphoblastic Leukemia Cells Antigen; ADP Ribosyl Cyclase 1; cADP-ribose Hydrolase 1; CD38H; NAD(+) Nucleosidase; NIM-R5 Antigen; p45; T10

Database Links

Entrez Gene ID
952
SwissProt
P28907

Additional Information

Clone
rCD38/6447
Chromosome Location
4p15
Mol. Weight of Antigen
~45kDa (Glycoprotein); 35kDa (protein core)

Related Antibodies

View All CD38 Antibodies

Functions

  • Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Key References

  • Deaglio S, et. al. J Immunol. 1998;160(1):395-402.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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