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B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody [B7H6/4821]

Additional information

Catalog Number: 374383-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
374383-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
374383-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
374383-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody

Formalin-fixed, paraffin-embedded human liver carcinoma in colon stained with B7-H6 / NCR3LG1 Mouse Monoclonal Antibody (B7H6/4821).

B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody - Image 2

Formalin-fixed, paraffin-embedded human tonsil stained with B7-H6 / NCR3LG1 Mouse Monoclonal Antibody (B7H6/4821).

B7-H6 Antibody in SDS-PAGE

B7-H6 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified B7-H6 Mouse Monoclonal Antibody (B7H6/4821). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
B7H6/4821
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
NCR3LG1
Positive Control
HeLa or K562 cells. Human tonsil or gallbladder.
Immunogen
Recombinant fragment (around aa38-169) of human NCR3LG protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Triggers NCR3-dependent natural killer cell activation.
Key References
  • Zhang, B, et al. Oncol Lett. 2019 Jul; 16(1): 91-96.
  • Brandt CS, et al. J Exp Med. 2009;206:1495 1503.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
374383
SwissProt
Q68D85
Chromosome Location
11p15.1
Mol. Weight of Antigen
51kDa
Alternate Names
Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, Natural cytotoxicity triggering receptor 3 ligand 1 (NCTR3L1); B7 Homolog 6 (B7H6)

Summary

B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.

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