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CD168 / RHAMM Antibody [HMMR/8021]

Additional information

Catalog Number: 3161-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

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In Stock
Catalog Number Formulation Size Price
3161-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3161-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3161-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD168 / RHAMM Antibody

Formalin-fixed, paraffin-embedded human placenta stained with CD168 / HMMR Mouse Monoclonal Antibody (HMMR/8021). Inset: PBS instead of primary antibody; secondary only negative control.

CD168 Antibody in SDS-PAGE

CD168 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified CD168 Mouse Monoclonal Antibody (HMMR/8021). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
HMMR/8021
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell Surface. Cytoplasm.
Gene Name
HMMR
Positive Control
breast cancer or placenta.|Human breast
Immunogen
Recombinant fragment (around aa1-250) of human HMMR protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
Key References
  • Jiang, Z., et al. 2021. Hyaluronan-mediated motility receptor governs chromosome segregation by regulating microtubules sliding within the bridging fiber. Adv. Biol. 5: e2000493.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3161
SwissProt
O75330
Chromosome Location
5q34
Mol. Weight of Antigen
85-90kDa
Alternate Names
Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168; CD168 antigen; HMMR; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility

Summary

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

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