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Recombinant Laminin Receptor / RPSA (Marker of Metastatic Potential) Antibody [RPSA/6332R]

Additional information

Catalog Number: 3921-RBM2
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3921-RBM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3921-RBM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3921-RBM2-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Laminin Receptor / RPSA (Marker of Metastatic Potential) Antibody

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). Inset: PBS instead of primary antibody; secondary only negative control.

Recombinant Laminin Receptor / RPSA (Marker of Metastatic Potential) Antibody - Image 2

Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant Laminin Receptor / RPSA (Marker of Metastatic Potential) Antibody - Image 3

Formalin-fixed, paraffin-embedded human colonstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

Laminin Receptor Antibody in SDS-PAGE

Laminin Receptor Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified RPSA Recombinant Rabbit Monoclonal Antibody (RPSA/6332R). Confirmation of Purity and Integrity of Antibody

Laminin Receptor Antibody in Western Blot (WB)

Laminin Receptor Antibody in Western Blot (WB)

Western Blot Analysis of Human Pancreas, Human Skin, Human Spleen, Human Stomach, HeLa and 3T3 lysates using Laminin Receptor Recombinant Rabbit Monoclonal Antibody (RPSA/6332R).

Laminin Receptor Antibody in Western Blot (WB)

Laminin Receptor Antibody in Western Blot (WB)

Western Blot Analysis of Pancreas, Skin and Spleen tissue lysates of different species using Laminin Receptor Recombinant Rabbit Monoclonal Antibody (RPSA/6332R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
RPSA/6332R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Cytoplasm, Nucleus
Gene Name
RPSA
Positive Control
colon or ovarian carcinoma., Human breast, Human Pancreas, Human Skin, Human Spleen, Human Stomach, HeLa and 3T3.
Immunogen
Recombinant full-length human Laminin Receptor protein
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA., (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9., (Microbial infection) Acts as a receptor for the Dengue virus., (Microbial infection) Acts as a receptor for the Sindbis virus., (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus., (Microbial infection) Acts as a receptor for the pathogenic prion protein., (Microbial infection) Acts as a receptor for bacteria.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3921
SwissProt
P08865
Chromosome Location
3p22.1
Mol. Weight of Antigen
32.85kDa
Alternate Names
Small ribosomal subunit protein uS2, 37LRP|67LR|ICAS|LAMBR|LAMR1|LBP|LBP/p40|LRP|LRP/LR|NEM/1CHD4|SA|lamR|p40|uS2

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.

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