ZNF358 (Zinc Finger Protein 358) (Transcription Factor) [PCRP-ZNF358-1A6]

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Summary

Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kr ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Kr ppel C2H2-type zinc finger protein family, ZNF358 (zinc finger protein 358) is a 481 amino acid nuclear protein that contains nine C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.

Product Properties & Targets

Host
Species Reactivity
Isotype
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or 293T cells.Human testis, spleen or colon.
Immunogen
Recombinant full-length human ZNF358protein
Alternate Names
Zinc finger protein 358, FLJ10390, ZFEND

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
PCRP-ZNF358-1A6
Human Gene Symbol
ZNF358
Chromosome Location
19p13.2
Mol. Weight of Antigen
53kDa.

Functions

  • May be involved in transcriptional regulation.

Known Applications & Suggested Dilutions

  • Immunoprecipitation (1-2ug per 100-500ug of total protein)
  • ,Western Blot (1-2ug/ml)
  • Immunofluorescence (1-2ug/ml)
  • ,Flow Cytometry (1-2ug/million cells)
  • ,Optimal dilution for a specific application should be determined.

Key References

  • Sutcliffe EG, et al. Cancer Genet, 2020 Aug. PMID 32805687

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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