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SDS-PAGE Analysis of Purified ZNF358 Mouse Monoclonal Antibody (PCRP-ZNF358-1A6). Confirmation of Purity and Integrity of Antibody.
Flow cytometric analysis of PFA-fixed HeLa cells. ZNF358 Mouse Monoclonal Antibody (PCRP-ZNF358-1A6) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Immunofluorescence analysis of PFA-fixed HeLa cells. ZNF358 Mouse Monoclonal Antibody (PCRP-ZNF358-1A6) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using ZNF358 Mouse Monoclonal Antibody (PCRP-ZNF358-1A6). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kr ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Kr ppel C2H2-type zinc finger protein family, ZNF358 (zinc finger protein 358) is a 481 amino acid nuclear protein that contains nine C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.
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