Free Shipping in the U.S. for orders over $1000.  Shop Now>>

Tubulin beta 3 / TUBB3 (Neuronal& Stem Cell Marker) Antibody [TUBB3/3732]

In Stock
Catalog Number Formulation Size Price
10381-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10381-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10381-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Cell projection, Cytoplasm, Cytoskeleton, Filopodium, Growth cone, Lamellipodium
Gene Name
Positive Control
A375, Raji orHEP2 cells. Human brain and testis., U87
Immunogen
A synthetic peptide (aa 437-450) of human Tubulin beta 3 protein (TUBB3); coupled to KLH.
Alternate Names
Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, beta 3 tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; M(beta)3; M(beta)6; MC1R; Neuron specific beta III Tubulin; Neuron-specific class III beta-tubulin; TUBB3; TUBB4; Tubulin beta-3; Tubulin beta-4; Tubulin beta-III

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
TUBB3/3732
Chromosome Location
16q24.3
Mol. Weight of Antigen
55kDa

Functions

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).

Key References

  • Osborn M et. al. European Journal of Cell Biology. 1984; 34:137-143.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “Tubulin beta 3 / TUBB3 (Neuronal& Stem Cell Marker) Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK