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Thyroid Stimulating Hormone, beta (TSH beta) (Pituitary Marker) Antibody [TSHb/1317]

In Stock
Catalog Number Formulation Size Price
7252-MSM1-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
7252-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7252-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical; however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Normal pituitary or pituitary tumor.
Immunogen
Recombinant human TSH beta fragment
Alternate Names
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, Thyrotropin beta chain, CHNG4; Thyroid stimulating hormone beta subunit; Thyroid stimulating hormone, beta precursor; Thyrotropin beta subunit; TSHB

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
TSHb/1317
Chromosome Location
1p13
Mol. Weight of Antigen
16kDa

Functions

  • Indispensable for the control of thyroid structure and metabolism.

Key References

  • Osamura R.Y., et al. Immunohistochemical studies of human FSH producing pituitary adenomas. Pathological anatomy and histopathology. (1988)

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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