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Stathmin 1 / STMN1 Antibody [STMN1/8439]

Additional information

Catalog Number: 3925-MSM9
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3925-MSM9-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3925-MSM9-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3925-MSM9-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Stathmin 1 / STMN1 Antibody

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Stathmin 1 Mouse Monoclonal Antibody (STMN1/8439). Inset: PBS instead of primary antibody; secondary only negative control.

Stathmin 1 / STMN1 Antibody - Image 2

SDS-PAGE Analysis of Purified Stathmin 1 Mouse Monoclonal Antibody (STMN1/8439). Confirmation of Purity and Integrity of Antibody.

Stathmin1 Antibody in Western Blot (WB)

Stathmin1 Antibody in Western Blot (WB)

Western Blot Analysis of Jurkat lysate using Stathmin1 Mouse Monoclonal Antibody (STMN1/8439).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
STMN1/8439
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cytoplasm. Cytoskeleton.
Gene Name
STMN1
Positive Control
Human brain or melanoma tissue. Jurkat.
Immunogen
Recombinant fragment of human STMN1 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Key References
  • Cai Y,et al. Cell Death Dis, 2022 Feb 24. PMID 35210426
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3925
SwissProt
P16949
Chromosome Location
1p36.11
Mol. Weight of Antigen
19kDa
Alternate Names
Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, C1orf215; Lag; LAP18; Leukemia associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein 19; Phosphoprotein p19; pp17; pp19; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin1; STMN 1

Summary

Op18 (for oncoprotein 18, also designated stathmin, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of Op18 are observed, and it is expressed as two different isoforms. Op18 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phophorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation.Op18 is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.

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