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Recombinant SOX11 (Mantle Cell Lymphoma Marker) Antibody [SOX11/3235R]

In Stock
Catalog Number Formulation Size Price
6664-RBM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6664-RBM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6664-RBM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).

Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).

Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).

Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of ~47kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus
Gene Name
SOX11
Positive Control
A431 or Y79 cells. Human cervix or mantle cell lymphoma (MCL).
Immunogen
Recombinant fragment (around aa300-400) of human SOX11 protein
Alternate Names
Transcription factor SOX-11, SOX11; SRY (sex determining region Y) box 11; SRY related HMG box gene 11; Transcription factor SOX-11

Database Links

Entrez Gene ID
6664
SwissProt
P35716

Additional Information

Clone
SOX11/3235R
Chromosome Location
2p25
Mol. Weight of Antigen
47kDa

Related Antibodies

View All SOX11 Antibodies

Functions

  • Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).

Key References

  • Osaki, E., et al. 1999. Identification of a novel SRY-related gene and its germ cell-specific expression. Nucleic Acids Res. 27: 2503-2510.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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