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SIGLEC10 Antibody [SIGLEC10/7581]

Additional information

Catalog Number: 89790-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
89790-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
89790-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
89790-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
SIGLEC10 Antibody

SDS-PAGE Analysis of Purified SIGLEC10 Mouse Monoclonal Antibody (SIGLEC10/7581). Confirmation of Purity and Integrity of Antibody.

SIGLEC10 Antibody - Image 2

Formalin-fixed, paraffin-embedded human small intestine stained with SIGLEC10 Mouse Monoclonal Antibody (SIGLEC10/7581). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
SIGLEC10/7581
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Cell surface. Secreted.
Gene Name
SIGLEC10
Positive Control
Expressed by peripheral blood leukocytes (eosinophils|lung|monocytes and a natural killer cell subpopulation). Isoform 5 is found in lymph node|ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow|spleen a
Immunogen
Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 3- or alpha-2, 6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Key References
  • Whitney, G., et al, M. 2001. A new siglec family member, Siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33. Eur. J. Biochem. 268: 6083-6096.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
89790
SwissProt
Q96LC7
Chromosome Location
17q21.33
Mol. Weight of Antigen
77kDa
Alternate Names
Sialic acid-binding Ig-like lectin 10, Siglec-like protein 2, mSiglec G; PRO940; sialic acid binding Ig like lectin 10 Ig like lectin 7; Sialic acid binding Immunoglobulin like lectin 10; Siglec G; siglec like gene 2; Siglec like protein 2; Siglecg; SLG2

Summary

Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.

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