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Recombinant Tyrosine Hydroxylase (Marker of Peripheral Neuroblastic Tumors) Antibody [TH/16182]

Additional information

Reactivity:

Gene:

Catalog Number: 7054-MSM19
In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7054-MSM19-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7054-MSM19-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7054-MSM19-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Tyrosine 3-monooxygenase / TH Antibody in SDS-PAGE

Tyrosine 3-monooxygenase / TH Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Tyrosine 3-monooxygenase / TH Mouse Monoclonal Antibody (TH/16182). Confirmation of Purity and Integrity of Antibody.

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  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Mouse Monoclonals
Species Reactivity
Human
Clone
TH/16182
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus
Gene Name
TH
Positive Control
kidney
Immunogen
Synthetic peptide corresponding to the C-terminal of human TH (epitope: aa520-528)
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). Lacks catalytic activity. Lacks catalytic activity.
Key References
  • Grima, B et al. “A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics.” Nature vol. 326,6114 (1987): 707-11. doi:10.1038/326707a0
  • Liu, Guoqian et al. “Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.” European journal of medical research vol. 29,1 228. 12 Apr. 2024, doi:10.1186/s40001-024-01703-z
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7054
SwissProt
P07101
Chromosome Location
11p15.5
Mol. Weight of Antigen
58kDa
Alternate Names
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, DYT14 | DYT5b | TYH

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