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Recombinant Tropomyosin alpha-1 chain Antibody [TPM1/9536R]

In Stock
Catalog Number Formulation Size Price
7168-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7168-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7168-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm, Cytoskeleton
Gene Name
TPM1
Positive Control
Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients
Immunogen
Recombinant full-length human TPM1 protein
Alternate Names
Tropomyosin alpha-1 chain, C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA

Database Links

Entrez Gene ID
7168
SwissProt
P09493

Additional Information

Clone
TPM1/9536R
Chromosome Location
15q22.2
Mol. Weight of Antigen
32.71kDa
Purification
Protein G

Related Antibodies

View All TPM1 Antibodies

Functions

  • Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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