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Recombinant Plasminogen Activator Inhibitor (Type 1) / PAI-1 (Breast Cancer Prognostic Marker) Antibody [rTJA6]

Additional information

Catalog Number: 5054-MSM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5054-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5054-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5054-MSM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Plasminogen Activator Inhibitor Antibody in Western Blot (WB)

Plasminogen Activator Inhibitor Antibody in Western Blot (WB)

Western blot analysis of A-431 cell lysate using PAI-1 Recombinant Mouse Monoclonal Antibody (rTJA6).

Plasminogen Activator Inhibitor Antibody in Immunohistochemistry (IHC (P))

Plasminogen Activator Inhibitor Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human testis stained with Recombinant Mouse Monoclonal Antibody (rTJA6). Inset: PBS instead of primary antibody; secondary only negative control.

Plasminogen Activator Inhibitor Antibody in SDS-PAGE

Plasminogen Activator Inhibitor Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified PAI-1 Recombinant Mouse Monoclonal Antibody (rTJA6). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rTJA6
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
SERPINE1
Positive Control
A-431 cells. Human placenta, lung or breast cancer.
Immunogen
Recombinant fragment (aa1-250) of human PAI-1 protein
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5054
SwissProt
P05121
Chromosome Location
7q22.1
Mol. Weight of Antigen
45.06kDa
Alternate Names
Plasminogen activator inhibitor 1, PAI|PAI-1|PAI1|PLANH1

Summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.

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