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Recombinant PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Antibody [PDL1/8809R]

Additional information

Catalog Number: 29126-RBM29
Gene:

Host:

Reactivity:

, , , , ,

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
29126-RBM29-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
29126-RBM29-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
29126-RBM29-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Antibody

Formalin-fixed, paraffin-embedded human placenta stained with PD-L1 Recombinant Rabbit Monoclonal Antibody (PDL1/8809R). Inset: PBS instead of primary antibody; secondary only negative control.

Recombinant PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Antibody - Image 2

SDS-PAGE Analysis of Purified PD-L1 Recombinant Rabbit Monoclonal Antibody (PDL1/8809R). Confirmation of Purity and Integrity of Antibody.

CD274 Antibody in Western Blot (WB)

CD274 Antibody in Western Blot (WB)

Western Blot Analysis of Human Lung and HeLa lysates using CD274 Rabbit Recombinant Monoclonal Antibody (PDL1/8809R).

CD274 Antibody in Western Blot (WB)

CD274 Antibody in Western Blot (WB)

Western Blot Analysis of Lung tissue lysates of different species using CD274 Rabbit Recombinant Monoclonal Antibody (PDL1/8809R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Guinea Pig, Hamster, Human, Mouse, Rabbit, Rat
Clone
PDL1/8809R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Early endosome membrane, Endomembrane system, Nucleus, Recycling endosome membrane, Secreted
Gene Name
CD274
Positive Control
Human placenta|spleen or tonsil tissue. Lung, HeLa.
Immunogen
Recombinant fragment (around aa272-290) of the human CD274 protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Host:

Reactivity:

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201)., The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
29126
SwissProt
Q9NZQ7
Chromosome Location
9p24.1
Mol. Weight of Antigen
33.27kDa
Alternate Names
Programmed cell death 1 ligand 1, ADMIO5|B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1|hPD-L1

Summary

PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.

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