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Recombinant OCT-2 (POU2F2) (B-Cell Marker) Antibody [rOCT2/7196]

In Stock
Catalog Number Formulation Size Price
5452-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5452-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5452-MSM6-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Transcription factor that specifically binds to the octamer motif (5′-ATTTGCAT-3′) (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874)., Activates the U2 small nuclear RNA (snRNA) promoter.

Product Properties & Targets

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
POU2F2
Positive Control
Isoform 3 is B-cell specific
Immunogen
Recombinant fragment (around aa112-297) of the human OCT-2 protein (exact sequence is proprietary)
Alternate Names
POU domain, class 2, transcription factor 2, OCT2|OTF2|Oct-2

Database Links

Entrez Gene ID
5452
SwissProt
P09086

Additional Information

Clone
rOCT2/7196
Chromosome Location
19q13.2
Mol. Weight of Antigen
51.21kDa
Expression System
HEK293 Cells
Purification
Protein G

Related Antibodies

View All POU2F2 Antibodies

Functions

  • Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874)., Activates the U2 small nuclear RNA (snRNA) promoter.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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