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Recombinant Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody [MSVA-561R]

In Stock
Catalog Number Formulation Size Price
3623-RBM15-P0
Purified Ab with BSA and Azide
20ug
$324.50
3623-RBM15-P1
Purified Ab with BSA and Azide
100ug
$599.50
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
INHA Antibody in Numerous Tissues (IHC)

INHA Antibody in Numerous Tissues (IHC)

Inhibin alpha chain Rabbit Recombinant Monoclonal Antibody (MSVA-561R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1:75-1:150
IHC Protocol
Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121°C in pH 7.8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:50 at 37°C for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer’s directions.

Summary

It recognizes a 47kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same 伪 subunit, covalently linked to 1 of 2 distinct subunits, 尾-伪 or 尾-尾. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor 尾 (TFG尾) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Secreted
Gene Name
INHA
Positive Control
Adrenal gland: A moderate to strong INHA positivity should be seen in adrenocortical cells.
Immunogen
Recombinant fragment of human Inhibin alpha protein (around aa 233-362) (exact sequence is proprietary)
Alternate Names
Inhibin alpha chain, A inhibin subunit; IHA; inhA; Inhibin alpha chain; Inhibin alpha subunit

Database Links

Entrez Gene ID
3623
SwissProt
P05111

Additional Information

Clone
MSVA-561R
Chromosome Location
2q35
Mol. Weight of Antigen
47kDa

Related Antibodies

View All INHA Antibodies

Functions

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Key References

  • Balanathan, P., et al. (2009) Elevated level of inhibin-αsubunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. British Journal of Cancer, 100(11), 1784 1793.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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