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Recombinant GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody [GLUT1/3132R]

Additional information

Catalog Number: 6513-RBM6
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6513-RBM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6513-RBM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6513-RBM6-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody

Formalin-fixed, paraffin-embedded human Tongue stained with GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R).

Recombinant GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R). Confirmation of Purity and Integrity of Antibody.

Recombinant GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody - Image 3

Flow Cytometric Analysis of K562 cells using GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R) followed by goat anti-rabbit IgG-CF488 (Blue); Isotype Control (Red).

GLUT-1 Antibody in Western Blot (WB)

GLUT-1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Skin tissue lysate using GLUT-1 Mouse Monoclonal Antibody (GLUT1/3132R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
GLUT1/3132R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Melanosome, Photoreceptor inner segment
Gene Name
SLC2A1
Positive Control
A431, colon and ovarian carcinoma., K562, MDA-MB-231 cells. Erythrocytes. Mesothelioma or breast, Skin
Immunogen
Recombinant fragment (around aa203-305) of the human GLUT-1 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6513
SwissProt
P11166
Chromosome Location
1p34.2
Mol. Weight of Antigen
54.08kDa
Alternate Names
Solute carrier family 2, facilitated glucose transporter member 1, CSE|DYT17|DYT18|DYT9|EIG12|GLUT|GLUT-1|GLUT1|GLUT1DS|HTLVR|PED|SDCHCN

Summary

Recognizes a protein of 55kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).

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