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Recombinant CD83 (Marker of Activated Dendritic Cells) Antibody [CD83/9818R]

In Stock
Catalog Number Formulation Size Price
9308-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
9308-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
9308-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Western Blot
Species Reactivity
Human
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Membrane
Gene Name
CD83
Positive Control
Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells
Immunogen
Recombinant human CD83 protein
Alternate Names
CD83 antigen, BL11|HB15

Database Links

Entrez Gene ID
9308
SwissProt
Q01151

Additional Information

Clone
CD83/9818R
Chromosome Location
6p23
Mol. Weight of Antigen
23.04kDa
Purification
Protein G

Related Antibodies

View All CD83 Antibodies

Functions

  • Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
PARTNERSHIP OPPORTUNITIES

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