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Recombinant CD45RO (T-Cell Marker) Antibody [PTPRC/2877R]

Additional information

Catalog Number: 5788-RBM30
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5788-RBM30-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5788-RBM30-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5788-RBM30-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD45RO (T-Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human Lymph Node stained with CD45RB Rabbit Recombinant Monoclonal Antibody (PTPRC/2877R).

Recombinant CD45RO (T-Cell Marker) Antibody - Image 2

Paraformaldehyde-fixed Raji cells stained with CD45RB Rabbit Recombinant Monoclonal Antibody (PTPRC/2877R)followed by Goat anti-rabbit IgG-CF488 (Green). Counterstain is Phalloidin (red).

Recombinant CD45RO (T-Cell Marker) Antibody - Image 3

Flow Cytometric Analysis of paraformaldehyde-fixed Raji cells using CD45RB Rabbit Recombinant Monoclonal Antibody (PTPRC/2877R) followed by Goat anti-rabbitIgG-CF488 (Blue); Isotype Control (Red).

CD45RB Antibody in Western Blot (WB)

CD45RB Antibody in Western Blot (WB)

Western Blot Analysis of human spleen lysate using CD45RB Rabbit Recombinant Monoclonal Antibody (PTPRC/2877R).

PTPRC Antibody in SDS-PAGE

PTPRC Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Receptor-type tyrosine-protein phosphatase C Recombinant Rabbit Monoclonal Antibody (PTPRC/2877R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Flow
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot, Flow
Species Reactivity
Human
Clone
PTPRC/2877R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Membrane raft, Synapse
Gene Name
PTPRC
Positive Control
Raji, Ramos, U-698 or GA-10 cells. Tonsil and Spleen.
Immunogen
Non-T, non-B CALLA positive ALL cell line REH
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity., (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5788
SwissProt
P08575
Chromosome Location
1q31.3-q32.1
Mol. Weight of Antigen
147.48kDa
Alternate Names
Receptor-type tyrosine-protein phosphatase C, B220|CD45|CD45R|GP180|IMD105|L-CA|LCA|LY5|T200

Summary

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.

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