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Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody [rCR2/1952]

Additional information

Catalog Number: 1380-MSM11
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
1380-MSM11-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
1380-MSM11-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
1380-MSM11-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human spleen stained with CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952).

Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human spleen stained with CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952).

Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952). Confirmation of Integrity and Purity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rCR2/1952
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CR2
Positive Control
WEHI-231 cells. Human tonsil (IHC).
Immunogen
Recombinant fragment (around aa44-196) of the human CD21 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed:1849076, PubMed:21527715, PubMed:7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed:21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed:1383329, PubMed:30107486). Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner (PubMed:12938232). Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production (PubMed:1386409)., (Microbial infection) Acts as a receptor for Epstein-Barr virus.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
1380
SwissProt
P20023
Chromosome Location
1q32.2
Mol. Weight of Antigen
112.91kDa
Alternate Names
Complement receptor type 2, C3DR|CD21|CR|CVID7|SLEB9

Summary

Recognizes a protein of 140kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

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