Recombinant CD137 / 4-1BB / TNFRSF9 Antibody [rS16]

Summary

CD137, a member of the tumor necrosis factor receptor family, and its ligand are expressed on activated T lymphocytes and on antigen-presenting cells, respectively. This receptor/ligand system regulates the activation, proliferation and survival of T and B lymphocytes and monocytes through bidirectional signal transduction. Human CD137 is also expressed on activated B cells, Reed Sternberg cells and peripheral blood monocytes but is absent from resting T cells. In non-lymphoid cells it has been detected in blood vessel walls, on the endothelial layer and on vascular smooth muscle cells. Soluble forms of CD137 are also found in sera. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma. It is a target for immunotherapy.