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Recombinant CD137 / 4-1BB / TNFRSF9 Antibody [r4-1BB/4603]

In Stock
Catalog Number Formulation Size Price
3604-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3604-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3604-MSM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD137 / 4-1BB / TNFRSF9 Antibody

Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603).

Recombinant CD137 / 4-1BB / TNFRSF9 Antibody - Image 2

SDS-PAGE Analysis of Purified CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

Product Properties & Targets

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Cell membrane
Gene Name
TNFRSF9
Positive Control
HEK293 or Jurkat cells. Human kidney or thyroid cancer tissues. Expressed on the surface of activated T-cells.
Immunogen
Recombinant full-length human CD137 protein
Alternate Names
Tumor necrosis factor receptor superfamily member 9, 4-1BB|CD137|CDw137|ILA|IMD109

Database Links

Entrez Gene ID
3604
SwissProt
Q07011

Additional Information

Clone
r4-1BB/4603
Chromosome Location
1p36.23
Mol. Weight of Antigen
27.9kDa
Expression System
CHO Cells
Purification
Protein A

Related Antibodies

View All TNFRSF9 Antibodies

Functions

  • Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

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