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Recombinant Calretinin / Calbindin 2 (Mesothelioma Marker) Antibody [rCALB2/4689]

In Stock
Catalog Number Formulation Size Price
794-MSM9-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
794-MSM9-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
794-MSM9-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Calretinin Antibody in Western Blot (WB)

Calretinin Antibody in Western Blot (WB)

Western Blot Analysis of Human Brain tissue lysate using Calretinin Recombinant Mouse Monoclonal Antibody (rCALB2/4689).

Calretinin Antibody in SDS-PAGE

Calretinin Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Calretinin Recombinant Mouse Monoclonal Antibody (rCALB2/4689). Confirmation of Purity and Integrity of Antibody.

Calretinin Antibody in Western Blot (WB)

Calretinin Antibody in Western Blot (WB)

Western Blot Analysis of Brain tissue lysates of different species using Calretinin Recombinant Mouse Monoclonal Antibody (rCALB2/4689).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

It recognizes a protein of about 29kDa, which is identified as Calretinin (also known as Calbindin 2). Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is present in subsets of neurons throughout the brain and spinal chord, including sensory ganglia. Antibody to calretinin is useful in differentiating mesothelioma from adenocarcinomas of the lung. It also aids in differentiating adrenal cortical neoplasms from pheochromocytomas.

Product Properties & Targets

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell projection, Dendrite, Synapse
Gene Name
CALB2
Positive Control
Brain, Testis or Mesothelioma.
Immunogen
Recombinant fragment (around aa23-242) of the human Calretinin (Calbindin 2) protein (exact sequence is proprietary)
Alternate Names
Calretinin, CAB29|CAL2|CR

Database Links

Entrez Gene ID
794
SwissProt
P22676

Additional Information

Clone
rCALB2/4689
Chromosome Location
16q22.2
Mol. Weight of Antigen
31.54kDa
Expression System
HEK293 Cells
Purification
Protein G

Related Antibodies

View All CALB2 Antibodies

Functions

  • Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (By similarity). During embryonic development, it facilitates neuronal differentiation and maturation (By similarity).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

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