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Recombinant BCL10 (MALT-Lymphoma Marker) Antibody [BL10/2988R]

Additional information

Catalog Number: 8915-RBM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
8915-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8915-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8915-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant BCL10 (MALT-Lymphoma Marker) Antibody

Formalin-fixed, paraffin-embedded human tonsil stained with BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R).

Recombinant BCL10 (MALT-Lymphoma Marker) Antibody - Image 2

Flow Cytometric Analysis of PFA-fixed K562 cells. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-Rabbit IgG-CF488 (blue); isotype control (red).

Recombinant BCL10 (MALT-Lymphoma Marker) Antibody - Image 3

Immunofluorescence Analysis of PFA-fixed K562 cells labeling BCL10. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-rabbit IgG-CF488 (green). Phalloidin counterstain (red).

BCL10 Antibody in Western Blot (WB)

BCL10 Antibody in Western Blot (WB)

Western Blot Analysis of K-562 and Raji lysates using BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R).

BCL10 Antibody in SDS-PAGE

BCL10 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified B-cell lymphoma/leukemia 10 Rabbit Monoclonal Antibody (BL10/2988R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
BL10/2988R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Membrane raft, Perinuclear region
Gene Name
BCL10
Positive Control
K562 or HepG2 cells. Human lymphoma, Raji
Immunogen
Recombinant fragment (around aa122-168) of the human BCL-10 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
8915
SwissProt
O95999
Chromosome Location
1p22.3
Mol. Weight of Antigen
26.25kDa
Alternate Names
B-cell lymphoma/leukemia 10, CARMEN|CIPER|CLAP|IMD37|c-E10|mE10

Summary

BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF B activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.

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