Formalin-fixed, paraffin-embedded human pancreas stained with PHOX2B Recombinant Rabbit Monoclonal Antibody (PHOX2B/7161R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human pancreas stained with PHOX2B Recombinant Rabbit Monoclonal Antibody (PHOX2B/7161R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with PHOX2B Recombinant Rabbit Monoclonal Antibody (PHOX2B/7161R). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with PHOX2B Recombinant Rabbit Monoclonal Antibody (PHOX2B/7161R). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

PHOX2B [PHOX2B/7161R]

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Summary

Paired homeobox protein 2B (PHOX2B) is a transcription factor located on chromosome 4p13, which is essential for the formation of autonomic ganglia in the autonomic nervous system.PHOX2B is expressed in neuroblastoma, brain and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2).

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Product Properties & Targets

Host
Rabbit
Species Reactivity
Human
Isotype
IgG
Cellular Localization
Nucleus
Gene Name
PHOX2B
Mol. Weight of Antigen
32kDa
Immunogen
Recombinant fragment of human PHOX2B protein (exact sequence is proprietary)

Database Links

Entrez Gene ID
8929
Unigene
87202
SwissProt
Q99453

Additional Information

Clone
PHOX2B/7161R
Human Gene Symbol
PHOX2B
Chromosome Location
4p13

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Johnson, K.R., et al. 1996. Mapping of the ARIX homeodomain gene to mouse chromosome 7 and human chromosome 11q13. Genomics 33:527-531.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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