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Pancreatic lipase / PNLIP Antibody [PNLIP/9038]

In Stock
Catalog Number Formulation Size Price
5406-MSM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5406-MSM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5406-MSM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

The lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Members of the AB hydrolase subfamily include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL), Pancreatic Lipase (PL), gastric lipase (GL) and LCAT. These family members play a crucial role in the metabolism of lipids. Pancreatic Lipase, also designated pancreatic triacylglycerol acyl hydrolase, is important for dietary fat absorption as it hydrolyses triglycerides into diglycerides, monoglycerides and free fatty acids.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Secreted.
Positive Control
Human pancreas.
Immunogen
Recombinant fragment (around aa 265-465) of human PNLIP protein (exact sequence is proprietary)
Alternate Names
Pancreatic triacylglycerol lipase, Pancreatic lipase; Pancreatic triacylglycerol lipase; PL; PNLIP; PNLIPD; PTL; Triacylglycerol acylhydrolase

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PNLIP/9038
Chromosome Location
10q25.3
Mol. Weight of Antigen
51kDa

Functions

  • Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.

Key References

  • Winkler, F.K., et al. 1990. Structure of human Pancreatic Lipase. Nature 343: 771-774.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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