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p73 (Tumor Suppressor) Antibody [P73/2531]

In Stock
Catalog Number Formulation Size Price
7161-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
7161-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
7161-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
p73 (Tumor Suppressor) Antibody

Formalin-fixed, paraffin-embedded human Skin stained with p73 Mouse Monoclonal Antibody (P73/2531).

p73 (Tumor Suppressor) Antibody - Image 2

SDS-PAGE Analysis of Purified p73 Mouse Monoclonal Antibody (P73/2531). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Nuclear Marker, Transcription Factors
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
TP73
Positive Control
HEK293 cell lysates. Human kidney or bladder carcinoma., HeLa, Jurkat
Immunogen
Recombinant full-length human TP73 protein
Alternate Names
Tumor protein p73, p53-like transcription factor, p53-related protein, p53-like transcription factor; p53-related protein; p73; TP73; Tumor protein p73

Database Links

Entrez Gene ID
7161
SwissProt
O15350

Additional Information

Clone
P73/2531
Chromosome Location
1p36.32
Mol. Weight of Antigen
73kDa

Related Antibodies

View All TP73 Antibodies

Functions

  • Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).

Key References

  • Ebelt H., et al. J Mol Cell Cardiol 45:411-9 (2008).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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