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Recombinant NUT1 / NUTM1 / Snurportin 1 [SNUPN/7351R]

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Summary

NUTM1 (NUT Midline Carcinoma Family Member 1) is a Protein Coding gene. Diseases associated with NUTM1 include Nut Midline Carcinoma and Spindle Cell Sarcoma. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2G.Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.

Product Properties & Targets

Host
Rabbit
Species Reactivity
Human
Isotype
IgG, kappa
Cellular Localization
Nucleus. Cytoplasm.
Gene Name
NUTM1
Positive Control
Human testis.
Immunogen
Recombinant fragment (around aa 900-1100) of human NUTM1 protein (exact sequence is proprietary)
Alternate Names
NUT family member 1, Nuclear protein in testis, NUT; Nuclear Protein in Testis; C15orf55; FAM22H; NUT Family Member 1; DKFZp434O192; Chromosome 15 Open Reading Frame 55

Database Links

Entrez Gene ID
10073
Unigene
29919
SwissProt
Q86Y26

Additional Information

Clone
SNUPN/7351R
Human Gene Symbol
NUTM1
Chromosome Location
15q24.2
Mol. Weight of Antigen
120kDa

Functions

  • Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Luo, W., et al.NUTM1-Rearranged NeoplasmsA Heterogeneous Group of Primitive Tumors with Expanding Spectrum of Histology and Molecular AlterationsAn Updated Review.Curr. Oncol.2021,28, 4485-4503. https://doi.org/10.3390/curroncol28060381

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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