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Mothers against decapentaplegic homolog 2 Antibody [PCRP-SMAD2-1B10]

In Stock
Catalog Number Formulation Size Price
4087-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4087-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4087-MSM1-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209).

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Isotype / Light Chain
IgG /
Cellular Localization
Cytoplasm, Nucleus
Gene Name
SMAD2
Positive Control
Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta
Immunogen
Recombinant full-length human SMAD2 protein
Alternate Names
Mothers against decapentaplegic homolog 2, CHTD8|JV18|JV18-1|LDS6|MADH2|MADR2|hMAD-2|hSMAD2

Database Links

Entrez Gene ID
4087
SwissProt
Q15796

Additional Information

Clone
PCRP-SMAD2-1B10
Chromosome Location
18q21.1
Mol. Weight of Antigen
52.31kDa
Purification
Protein A

Related Antibodies

View All SMAD2 Antibodies

Functions

  • Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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