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MCM3 (Proliferation Marker) Antibody [MCM3/6706]

Additional information

Catalog Number: 4172-MSM4
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4172-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4172-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4172-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
MCM3 (Proliferation Marker) Antibody

Formalin-fixed, paraffin-embedded human tonsil stained with MCM3 Mouse Monoclonal Antibody (MCM3/6706). Inset: PBS instead of primary antibody, secondary only control.

MCM3 (Proliferation Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human colon carcinoma stained with MCM3 Mouse Monoclonal Antibody (MCM3/6706). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

MCM3 (Proliferation Marker) Antibody - Image 3

Formalin-fixed, paraffin-embedded human testis stained with MCM3 Mouse Monoclonal Antibody (MCM3/6706). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

MCM3 (Proliferation Marker) Antibody - Image 4

SDS-PAGE Analysis of Purified MCM3 Mouse Monoclonal Antibody (MCM3/6706). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
MCM3/6706
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Nucleus.
Gene Name
MCM3
Positive Control
MCF-7, Jurkat or Ramos cells. Human colon or tonsil.
Immunogen
Recombinant fragment (aa 650-750) of human MCM3 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable).
Key References
  • Koonin, E.V. 1993. Nucleic Acids Res. 21: 2541-2547.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4172
SwissProt
P25205
Chromosome Location
6p12.2
Mol. Weight of Antigen
115kDa
Alternate Names
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, Cervical cancer proto-oncogene 5; DNA polymerase alpha holoenzyme-associated protein P1; DNA replication factor MCM3; DNA replication licensing factor mcm3; HCC5; hRlf beta subunit; Human cervical cancer proto oncogene 5; MGC1157; Minichromosome maintenance complex component 3; Minichromosome maintenance deficient 3; P102 protein; Replication licensing factor beta subunit; RLF beta subunit; RLF subunit beta

Summary

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

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