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Lymphocyte Specific Protein 1 (LSP1) / pp52 Antibody [LSP1/3042]

In Stock
Catalog Number Formulation Size Price
4046-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
4046-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
4046-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
Positive Control
Colon, Human tonsil, spleen or Hodgkin's lymphoma (IHC-P).
Immunogen
Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
Alternate Names
Lymphocyte-specific protein 1, 47 kDa actin-binding protein, 52 kDa phosphoprotein, Lymphocyte-specific antigen WP34, WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
LSP1/3042
Chromosome Location
11p15.5
Mol. Weight of Antigen
52kDa

Functions

  • May play a role in mediating neutrophil activation and chemotaxis.

Key References

  • Pulford K., et al. Immunology. 1999 Feb;96(2):262-71.
  • Zhang H., et al. FEBS Open Bio. 2016 Nov 7;6(12):1227-1237.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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