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Interleukin-7 (IL-7) Antibody [IL7/4012]

In Stock
Catalog Number Formulation Size Price
3574-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3574-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3574-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor 纬 chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
IL7
Positive Control
Human thymus or tonsil tissue.
Immunogen
Recombinant fragment (around aa 27-177) corresponding to mature protein of human IL7(exact sequence is proprietary)
Alternate Names
Interleukin-7, IL 7; IL-7; Il7; Interleukin 7; Interleukin-7; LP-1; Lymphopoietin 1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IL7/4012
Chromosome Location
8q12-q13
Mol. Weight of Antigen
25kDa

Functions

  • Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Key References

  • Strauchen JA, Breakstone BA. Am J Pathol. 1987;126(3):506 512.Reche PA, et al. Journal of Immunology. 2001;167(1):336 343. doi:10.4049/jimmunol.167.1.336

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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