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Interleukin-25 (IL-25) / IL-17E Antibody [IL25/625]

In Stock
Catalog Number Formulation Size Price
64806-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
64806-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
64806-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV-13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length that is highly expressed in spleen and kidney.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human brain, kidney or lung.
Immunogen
Recombinant fragment of human IL25 protein (exact sequence is proprietary)
Alternate Names
Interleukin-25, Interleukin-17E, IL-17E; IL-25; IL17e; IL25; Interleukin 17E; Interleukin 25; Interleukin-17E

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IL25/625
Chromosome Location
14q11.2
Mol. Weight of Antigen
20kDa

Functions

  • Induces activation of NF-kappa-B and stimulates production of the pro-inflammatory chemokine IL-8. Pro-inflammatory cytokine favoring Th2-type immune responses.

Key References

  • Pan, G., et al. 2001. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J. Immunol. 167: 6559-6567.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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