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IL-10R1, Mouse (Interleukin-10 Receptor 1) (CD210) Antibody [1B1.3a]

Additional information

Catalog Number: RTM1-2001
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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IL-10R1, Mouse (Interleukin-10 Receptor 1) (CD210) Antibody

SDS-PAGE Analysis of Purified IL-10R1 Rat Monoclonal Antibody (1B1.3a). Confirmation of Integrity and Purity of Antibody.

  • Flow
  • IF
In Stock
Catalog Number Formulation Availability Size Price
RTM1-2001-P0
Purified Ab with BSA and Azide at 200ug/ml
Trial Size
In Stock
20ug
$259.00
Trial Size Available In-Stock
RTM1-2001-P1
Purified Ab with BSA and Azide at 200ug/ml
In Stock
100ug
$559.00
In-Stock
RTM1-2001-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Carrier-Free
In Stock
100ug
$559.00
Carrier-Free Available In-Stock
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Clone
1B1.3a
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane, Cytoplasm
Gene Name
Il10ra
Positive Control
Lung or Liver., lymph node, MPBMC's. Spleen, Placenta, Thymus
Immunogen
Purified recombinant extracellular region of Mouse IL10RA
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (By similarity).
Key References
  • Wang W, et al. 2004. FASEB J. 18:1043. (Neutralization
  • Vieira PL, et al. 2004. J. Immunol. 172:5986. (Neutralization)
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
16154
SwissProt
Q61727
Chromosome Location
9 A5.2; 9 24.84 cM (Mouse)
Mol. Weight of Antigen
90-110kDa
Alternate Names
Interleukin-10 receptor subunit alpha, CDw210a, Interleukin-10 receptor subunit 1, CD210 antigen; CDw210a; IBD28; IL10R alpha; IL-10R subunit 1; IL-10R1; IL10RA IL10RIL-10R subunit alpha; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; Interleukin-10 receptor subunit 1

Summary

This monoclonal antibody recognizes Mouse Interleukin-10 receptor 1 (IL-10R1), a cell surface glycoprotein of approximately 110KDa. Its epitope is localized in the ligand-binding domain in the extracellular region of Mouse IL-10R1. This antibody blocks the binding of IL-10 to its receptor. IL-10R1 is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation.

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