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HBsAg (Hepatitis B surface Ag a determinant) Antibody [HBsAg/387]

Additional information

Catalog Number: MSM1-387
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
MSM1-387-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
MSM1-387-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
MSM1-387-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
HBsAg Antibody in SDS-PAGE

HBsAg Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified HBsAg Mouse Monoclonal Antibody (HBsAg/387). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Clone
HBsAg/387
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Cytoplasm
Gene Name
HBsAg
Positive Control
HBsAg positive samples.
Immunogen
Recombinant fragment (around aa124-147) of HBsAg determinant "a" protein (exact sequence is proprietary)
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
  • The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Key References
  • Aden, D.P., et al. 1979. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282: 615-616.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2828293
SwissProt
P03138
Chromosome Location
N/A
Mol. Weight of Antigen
42kDa
Alternate Names
Large envelope protein, L glycoprotein, L-HBsAg, Large S protein, Large surface protein, Major surface antigen, HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S antibody

Summary

Hepatitis B surface antigen (HBsAg) is a glycoprotein on the surface of hepatitis B virus. After hepatitis B infection, HBsAg appears as the first viral marker. HBsAg can be detected in blood, saliva, breast milk, sweat, tears, nasopharyngeal secretions, semen and vaginal secretions of patients 2 to 6 months after infection with HBV. HBsAg antibodies are mainly used for the diagnosis of hepatitis B virus.

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