SDS-PAGE Analysis Purified GDF9 Rat Monoclonal Antibody (GDF9/4262) Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis Purified GDF9 Rat Monoclonal Antibody (GDF9/4262) Confirmation of Integrity and Purity of Antibody.

Printable Datasheet

GDF9 (Growth Differentiation Factor 9) [GDF9/4262]

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Summary

GDF9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9/4262 can be used in assays to detect GDF9 expression and help diagnose ovarian disorders.

Product Properties & Targets

Host
Rat
Applications
ELISA, Western Blot
Species Reactivity
Human
Isotype
IgG1
Cellular Localization
Secreted
Gene Name
GDF9
Positive Control
Human ovary.
Immunogen
N-terminal of GDF9, corresponding to sequence KKPLGPASFNLSEYFC.
Alternate Names
Growth/differentiation factor 9, Growth/differentiation factor 9, GDF-9, GDF9

Database Links

Entrez Gene ID
2661
Unigene
25022
SwissProt
O60383

Additional Information

Clone
GDF9/4262
Human Gene Symbol
GDF9
Chromosome Location
5q31.1
Mol. Weight of Antigen
51kDa

Functions

  • Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • Western Blot (1-2ug/ml)
  • ,Optimal dilution for a specific application should be determined.

Key References

  • Gilchrist, R.B., et al. (2004) Immunoneutralization of Growth Differentiation Factor 9 Reveals It Partially Accounts for Mouse Oocyte Mitogenic Activity. Biol Reprod; 71 (3): 732-739.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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