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GBX2 / Gastrulation Brain Homeobox 2 Antibody [GBX2/7235]

Additional information

Catalog Number: 2637-MSM5
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

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In Stock
Catalog Number Formulation Size Price
2637-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2637-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2637-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
GBX2 / Gastrulation Brain Homeobox 2 Antibody

SDS-PAGE Analysis of Purified GBX2 Mouse Monoclonal Antibody (GBX2/7235). Confirmation of Purity and Integrity of Antibody.

GBX2 / Gastrulation Brain Homeobox 2 Antibody - Image 2

Formalin-fixed, paraffin-embedded human brain stained with GBX2 Mouse Monoclonal Antibody (GBX2/7235). Inset: PBS instead of primary antibody; secondary only negative control.

GBX2 / Gastrulation Brain Homeobox 2 Antibody - Image 3

Formalin-fixed, paraffin-embedded human kidney stained with GBX2 Mouse Monoclonal Antibody (GBX2/7235). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
GBX2/7235
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Nucleus.
Gene Name
GBX2
Positive Control
Human placenta or brain.
Immunogen
Recombinant fragment (around aa150-350) of human GBX2 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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5
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Reactivity:

, , , ,

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Gene:

Host:

Reactivity:

, , ,

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Other Information

Functions
  • May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Key References
  • Bouillet, P., et al. 1995. Sequence and expression pattern of the Stra7 (GBX2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dyn. 204: 372-382.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2637
SwissProt
P52951
Chromosome Location
2q37.2
Mol. Weight of Antigen
37kDa
Alternate Names
Homeobox protein GBX-2, Gastrulation and brain-specific homeobox protein 2, Gastrulation and brain-specific homeobox protein 2; Gastrulation brain homeobox 2; Homeobox protein GBX2; Homeobox protein STRA7; Mmoxa

Summary

The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis; GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

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