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FSH-beta (Follicle Stimulating Hormone-beta) Antibody [FSHB/6845]

Additional information

Catalog Number: 2488-MSM5
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2488-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2488-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2488-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
FSH-beta (Follicle Stimulating Hormone-beta) Antibody

Formalin-fixed, paraffin-embedded human pituitary tissue stained with FSH beta Mouse Monoclonal Antibody (FSHB/6845). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

FSH-beta (Follicle Stimulating Hormone-beta) Antibody - Image 2

SDS-PAGE Analysis of Purified FSH beta Mouse Monoclonal Antibody (FSHB/6845). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
FSHB/6845
Isotype
IgG3
Light Chain
Kappa
Cellular Localization
Cytoplasm. Secreted.
Gene Name
FSHB
Positive Control
Human anterior pituitary gland.
Immunogen
Recombinant fragment (around aa1-100) of human FSHB (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).
Key References
  • Schmidt M et al. Pathol Res Pract. 2001;197(10):663-9
  • La Rosa S et al. Virchows Arch. 2000 Sep;437(3):264-9
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2488
SwissProt
P01225Human
Chromosome Location
11p13
Mol. Weight of Antigen
22kDa
Alternate Names
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, Follitropin beta chain, Follicle stimulating hormone beta polypetide; Follicle stimulating hormone beta subunit; Follitropin beta chain; Follitropin subunit beta; FSH-B; FSH-beta; FSHB; FSHbeta

Summary

Follicle stimulating hormone (FSH) is a hormone synthesized and secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of androgen-binding protein by the Sertoli cells of the testis and is critical for spermatogenesis. FSH and LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors and the study of pituitary disease.

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