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FGF23 (Fibroblast Growth Factor 23) Antibody [FGF23/638]

Additional information

Catalog Number: 8074-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
8074-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8074-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8074-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
FGF23 (Fibroblast Growth Factor 23) Antibody

SDS-PAGE Analysis of Purified FGF23 Mouse Monoclonal antibody (FGF23/638). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Functional Studies
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Functional Studies
Species Reactivity
Human
Clone
FGF23/638
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
FGF23
Positive Control
Human PBL cells. Brain tumors.
Immunogen
Recombinant human FGF23 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Key References
  • Yamashita, T., et al. 2000. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun. 277: 494-498.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
8074
SwissProt
Q9GZV9
Chromosome Location
12p13.32
Mol. Weight of Antigen
12-32kDa
Alternate Names
Fibroblast growth factor 23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, ADHR; FGF-23; FGFN; Fibroblast growth factor 23; HPDR2; HYPF; Phosphatonin; PHPTC; Tumor-derived hypophosphatemia-inducing factor

Summary

Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in trans- fected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

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