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Recombinant Factor XIIIa (Coagulation Factor XIIIA Chain) Antibody [F13A1/3772R]

These antibodies perform exceptionally well in the intended applications and have undergone stringent testing and additional validation to ensure monospecificity.

The MAbMan recommends these antibodies for repeatable and reliable results.

Additional information

Catalog Number: 2162-RBM6
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2162-RBM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2162-RBM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2162-RBM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Factor XIIIa (Coagulation Factor XIIIA Chain) Antibody

Formalin-fixed, paraffin-embedded human placenta stained with Factor 13A Recombinant Rabbit Monoclonal Antibody (F13A1/3772R).

Recombinant Factor XIIIa (Coagulation Factor XIIIA Chain) Antibody - Image 2

Formalin-fixed, paraffin-embedded human placenta stained with Factor 13A Recombinant Rabbit Monoclonal Antibody (F13A1/3772R).

Factor XIIIa Antibody in SDS-PAGE

Factor XIIIa Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified F13A1 Recombinant Rabbit Monoclonal Antibody (F13A1/3772R). Confirmation of Purity and Integrity of Antibody

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
F13A1/3772R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
F13A1
Positive Control
Human placenta tissue (IHC).
Immunogen
Recombinant fragment of human Factor XIIIa protein (aa46-181) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Key References
  • Davie, EW. et al. 1991. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 30: 10363-10370.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2162
SwissProt
P00488
Chromosome Location
6p25.3-p24.3
Mol. Weight of Antigen
83kDa
Alternate Names
Coagulation factor XIII A chain, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain, Coagulation factor XIII A chain; Coagulation factor XIII A1 polypeptide; F13A; F13a1; Fibrin stabilizing factor, A subunit; Fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase. plasma

Summary

It recognizes a protein of 83kDa, which is identified as Factor XIIIa. It has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-). Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.

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