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EZH2 / KMT6 Antibody [EZH2/6988]

Additional information

Catalog Number: 2146-MSM8
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2146-MSM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
2146-MSM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2146-MSM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
EZH2 / KMT6 Antibody

FFPE human Lynch syndrome colon carcinoma stained with EZH2 / KMT6 Mouse Monoclonal Antibody (EZH2/6988). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

EZH2 / KMT6 Antibody - Image 2

Formalin-fixed, paraffin-embedded human bladder carcinoma stained with EZH2 / KMT6 Mouse Monoclonal Antibody (EZH2/6988). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

EZH2 / KMT6 Antibody - Image 3

Formalin-fixed, paraffin-embedded human bladder carcinoma stained with EZH2 / KMT6 Mouse Monoclonal Antibody (EZH2/6988). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

EZH2 Antibody in Western Blot (WB)

EZH2 Antibody in Western Blot (WB)

Western Blot Analysis of Jurkat cell lysate using EZH2 / KMT6 Mouse Monoclonal Antibody (EZH2/6988).

EZH2 Antibody in SDS-PAGE

EZH2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Histone-lysine N-methyltransferase EZH2 Mouse Monoclonal Antibody (EZH2/6988). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
EZH2/6988
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Nucleus
Gene Name
EZH2
Positive Control
HeLa, MCF7, U-2 OS or HEK-293 cells. Human tonsil, testis or prostate tissue.
Immunogen
Recombinant fragment (around aa16-180) of human EZH2 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Gene:

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
Key References
  • Han Li C et. al. Curr Protein Pept Sci. 2015;16(6):559-70.
  • Yamagishi M et al. Curr Opin Oncol. 2017 Sep;29(5):375-381.
  • Shinozaki-Ushiku, A. et al. Histopathology 2017; 70, 722-733.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2146
SwissProt
Q15910
Chromosome Location
7q36.1
Mol. Weight of Antigen
81-102kDa
Alternate Names
Histone-lysine N-methyltransferase EZH2, ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6, Enhancer of zeste 2 polycomb repressive complex 2 subunit; Enhancer of zeste homolog 2 (EZH2); ENX1; Enx1h; EZH2b; Histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; Lysine N-methyltransferase 6; WVS; WVS2

Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

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